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Cand.scient, public health science., Ph.D. student.
Determinants and occurrence of long-term health consequences of early-onset obesity among men
Initiated: November 1st 2006
Ends on: February 10th 2010
Obesity rates have increased markedly in recent years. Several studies have observed an association between early-onset obesity, cardiovascular diseases and premature death in adult life. Despite of this association, the health prognosis for the obese is very heterogeneous, since not all experience obesity-related diseases. Therefore, this study investigates the health prognosis in adult life among early-onset obese men, including investigation of possible mediating or modifying factors, and the role of the weight history for the prognosis. The subjects were originally identified in an epidemiological study of obesity in young men, who underwent the mandatory draft board examination, in Copenhagen and the surrounding provincial areas. In this population, an obese cohort was identified who, according to a national standard, was 35 % or more overweight, corresponding to a BMI (body mass index) >=31 (n=1930). A control cohort of 1 % of the same population was randomly selected (n=3601). Since the draft board examination all men are followed-up via linkage to Danish registers. Subgroups of the two cohorts of men were invited to participate in re-examinations, as part of the Copenhagen City Heart Study surveys in 1981-83 and 1991-94. The fourth and last examination was conducted in 1998-2000. The average ages at baseline and the following surveys were 19, 32, 44 and 55 years, respectively. The follow-up surveys included anthropometric measurements, measurement of blood pressure, blood samples, as well as self-completed questionnaires. Methods from survival analysis are adapted for analysing the longitudinal data, where BMI is the exposure variable and T2D, cardiovascular diseases and death are the outcome variables. Data will be analysed in multi-state models, using Cox regression analysis.
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